High mpv levels1/10/2024 Usually, this disease with protean manifestations has a remitting relapsing course however, it has a tendency to vary from acutely progressive to chronic indolent forms 1, 2. There are racial and ethnic variations, with higher rates reported in Black and Hispanic peoples 2. It has an annual incidence of 5 per 100,000 of the general population 1. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect any organ system of the body. Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV. For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001). However, there was a strong positive correlation between ESR and SLEDAI (r s=0.90, P<0.001). Results: The MPV of patients with active SLE (n=25, mean =7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). Sensitivity and specificity of MPV were checked through ROC analysis. Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). MPV was measured in each group and compared using SPSS version 16. ![]() On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively 25 patients with active SLE, and another 25 participants with stable, inactive lupus. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker.
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